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What is Prolia?

Prolia (denosumab) is a prescription drug used for treating osteoporosis (a condition characterized by weak, fragile bones) in postmenopausal women. Many women are at a high risk for sustaining fractures due to weak bones after menopause. Prolia may also be given to people who have not been successfully treated using other therapies, and may be used in men.

How does Prolia Work?

Prolia is a manmade antibody designed to bind to a protein receptor on the surface of bone cells known as osteoclasts. These cells are responsible for bone breakdown. Prolia slows down osteoclast formation, activity, and survival, thereby reducing bone breakdown and promoting normal bone formation.

How is it Used?

Prolia is an injectable drug administered under the skin every six months. It is generally very well tolerated, but may rarely cause low calcium levels, atypical fractures, and jaw problems.